| API | 中间体产品名称 Product Name | CAS NO | 结构式 Structure | 适应症 Indication |
| 妥卡替尼 Tucatinib | 7-羟基-[1,2,4]三唑并[1,5-A]吡啶 [1,2,4]triazolo[1,5-a]pyridin-7-ol | 1033810-70-6 |  | 晚期/转移性乳腺癌 |
| 4-（[1,2,4]三唑[1,5-a]吡啶-7-氧基）-3-甲基苯胺 4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)-3-methylaniline | 937263-71-3 |  | ||
| 阿贝西利 Abemaciclib | 2-溴-4-氟-2-甲基-1-(1-甲基乙基)-1H-苯并咪唑 5-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole | 1231930-33-8 |  | HR+/HER2-乳腺癌 |
| 2,4-二氯-5-氟嘧啶 2,4-Dichloro-5-fluoropyrimidine | 2927-71-1 |  | ||
| 5-[(4-乙基哌嗪-1-基)甲基]吡啶-2-胺 5-[(4-Ethyl-1-piperazinyl)methyl]-2-pyridinamine | 1180132-17-5 |  | ||
| 6-(2-氯-5-氟-4-嘧啶基)-4-氟-1-异丙基-2-甲基-1H-苯并咪唑 6-(2-Chloro-5-fluoro-4-pyrimidinyl)-4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazole | 1231930-42-9 |  | ||
| 尼洛替尼 Nilotinib | 3-(4-甲基-1H-咪唑-1-基)-5-(三氟甲基)苯胺 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)aniline | 641571-11-1 |  | 慢性粒细胞白血病 |
| 伊马替尼 Imatinib | N-(5-氨基-2-甲基苯基)-4-(3-吡啶基)-2-氨基嘧啶 N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine | 152460-10-1 |  | 慢性粒细胞性白血病 |
| 4-[(4-甲基哌嗪-1-基)甲基]苯甲酸二盐酸盐 4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride | 106261-49-8 |  | ||
| 伊布替尼 Ibrutinib | 3-(4-苯氧基苯基)-1H-吡唑并[3,4-d]嘧啶-4-胺 3-(4-Phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine | 330786-24-8 |  | 慢性淋巴细胞白血病 |
| 哌柏西利 Palbociclib | 6-溴-2-氯-8-环戊基-5-甲基-吡啶并[2,3-D]嘧啶-7(8H)-酮 6-broMo-2-chloro-8-cyclopentyl-5-Methylpyrido[2,3-d]pyriMidin-7(8H)-one | 1016636-76-2 |  | HR+/HER2-晚期乳腺癌 |
| 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯 tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | 571188-59-5 |  | ||
| 卢卡帕利 Rucaparib | 8-氟-2-（4-甲胺甲基-苯基）-1,3,4,5-四氢-氮杂卓并（5,4,3-cd)-6-酮盐酸盐 Rucaparib intermediate | 773059-19-1 |  | 卵巢癌 |
| 仑伐替尼 Lenvatinib | 仑伐替尼游离碱 Lenvatinib | 417716-92-8 |  | 肾细胞癌 |
| 卡培他滨 Capecitabine | 1,2,3-三乙酰氧基-5-脱氧-D-核糖 1,2,3-triacetyl-5-deoxy-β-D-Riboturanose | 62211-93-2 |  | 晚期乳腺癌和结、直肠癌 |
| 拉帕替尼 Lapatinib | 3-氯-4-(3-氟苄氧基)苯胺 3-Chloro-4-[(3-fluorobenzyl)oxy]aniline | 202197-26-0 |  | 晚期/转移性乳腺癌 |
| 4-氯-6-碘喹唑啉 4-Chloro-6-iodoquinazoline | 98556-31-1 |  | ||
| 6-甲醛基呋喃-2-硼酸 2-Formylfuran-5-boronic acid | 27329-70-0 |  | ||
| 2-(甲砜基)乙胺盐酸盐 2-Aminoethylmethylsulfone hydrochloride | 104458-24-4 |  | ||
| 培唑帕尼 Pazopanib | 2,3-二甲基-6-氨基-2H-吲唑盐酸盐 2,3-Dimethyl-2H-indazol-6-amine hydrochloride | 635702-60-2 |  | 晚期肾细胞癌 |
| 3-氨基-6-甲基苯磺酰胺 5-Amino-2-methylbenzenesulfonamide | 6973-09-7 |  | ||
| 恩杂鲁胺 Enzalutamide | 4-异硫代氰酰基-2-(三氟甲基)苯甲腈 3-Fluoro-4-methylphenylisothiocyanate | 143782-23-4 |  | 前列腺癌 |
| 4-溴-2-氟苯甲酸 4-Bromo-2-fluorobenzoic acid | 112704-79-7 |  | ||
| 达罗他胺 Darolutamide | 2-氯-4-(1H-吡唑-3-基)苯甲腈 2-Chloro-4-(1H-Pyrazol-5-Yl)Benzonitrile | 1297537-37-1 |  | 前列腺癌 |
| 5-乙酰基吡唑-3-羧酸 5-Acetyl-1H-Pyrazole-3-carboxylic acid | 1297537-45-1 |  | ||
| 奥希替尼 Osimertinib | (4-溴-3-(乙氧基甲基)苯基)甲醇 (4-bromo-3-(ethoxymethyl)phenyl)methanol | 1255948-71-0 |  | 晚期/转移性非小细胞肺癌 |
| 阿来替尼 Alectinib | 4-(4-哌啶基)吗啉 4-Morpholinopiperidine | 53617-35-9 |  | 晚期或转移性非小细胞肺癌 |
| 2-(4-乙基苯基)-2-甲基丙酸 2-(4-ethylphenyl)-2-Methylpropanoic acid | 1247119-83-0 |  | ||
| 瑞波西利 Ribociclib | 4-(6-氨基吡啶-3-基)哌嗪-1-羧酸叔丁酯 tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | 571188-59-5 |  | 早期乳腺癌 |
| 2-氯-7-环戊基-N,N-二甲基-7H-吡咯并[2,3-D]嘧啶-6-羧酰胺 2-Chloro-7-cyclopentyl-N,N-dimethyl-H-pyrrolo[2,3-d]pyrimidine-6-carboxamide | 1211443-61-6 |  | ||
| 卡匹色替 Capivasertib | N-BOC-氨基-哌啶基-1,1-羧酸 N-boc-amino-piperidinyl-1,1-carboxylic acid | 252720-31-3 |  | HR+/HER2-乳腺癌 |
| (S)-对氯-Β-苯丙氨醇 (3S)-3-amino-3-(4-chlorophenyl)propan-1-ol | 886061-26-3 |  | ||
| 艾拉司群 Elacestrant | N-乙基-2-(4-甲酰基苯基)乙酰胺 Benzeneacetamide, N-ethyl-4-formyl- | 2477812-42-1 |  | ER+/HER2- 晚期乳腺癌 |
| N-乙酰基-2-溴-5-甲氧基苯胺 N-(2-bromo-5-methoxyphenyl)acetamide | 123027-99-6 |  | ||
| 7-苄氧基-3-溴-1,2-二氢萘 7-(benzyloxy)-3-broMo-1,2-dihydronaphthalene | 722536-73-4 |  | ||
| 奈拉替尼 Neratinib | 乙酰氨基-2-氨基-4-乙氧基苯甲酸甲酯 Methyl 5-acetamido-2-amino-4-ethoxybenzoate | 1222172-49-7 |  | HER-2阳性的早期乳腺癌 |
| [3-氯-4-(吡啶-2-甲氧基)苯基]甲胺 3-Chloro-4-[(pyridin-2-yl)methyloxy]aniline | 524955-09-7 |  |
